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Chlorobutanol

Chlorobutanol API

As a detergent, chlorobutanol disrupts the lipid structure of the cell membrane and increases the cell permeability, leading to cell lysis . It induces conjunctival and corneal cell toxicity via causing cell retraction and cessation of normal cytokines, cell movement, and mitotic activity

Chlorobutanol API

Cas No :

57-15-8
Name :

Chlorobutanol
Synonyms :

1,1,1-Trichloro-2-methylpropan-2-ol
Molecular Formula :

C4H7Cl3O
Melting Point :

95–99 °C
Boiling Point :

167 °C
Molecular Weight :

175.5 g/mol
Density :

1.088 g/cm3
Solubility :

Easily sol in hot water; one gram dissolves in 1 ml alcohol, 10 ml glycerol; sol in chloroform, ether, acetone, petr ether, glacial acetic acid, oils. Soluble in alcohol and glycerol, hot water, ether, chloroform, and volatile oils.

Uses :


  • Chlorobutanol is a common detergent preservative in eye drops and other ophthalmic therapeutic formulations. Chlorobutanol is a tertiary alcohol. A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables.

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