Rabeprazole API

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug – in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.

Rabeprazole API

Cas No :

117976-89-3

Name :

Rabeprazole

Synonyms :

(RS)-2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole

Molecular Formula :

C18H21N3O3S

Melting Point :

140-141° C

Boiling Point :

603.9 °C at 760 mmHg

Molecular Weight :

359.444 g/mol

Density :

1.3±0.1 g/cm3

Solubility :

Very soluble in water and methanol, freely soluble in ethanol, chloroform, and ethyl acetate, and is insoluble in ether and n-hexane.

Uses :


  • Rabeprazole is used to treat duodenal ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome, a condition where the stomach produces too much acid. It may also be used together with antibiotics (eg, amoxicillin, clarithromycin) to treat ulcers associated with infections caused by the H.